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Whom it may be suitable for: Can be ideal for the elderly because of fewer side effects when prescribed at lower doses.

Pros: A very effective SSRI that can be easier to start and stay on than others.

Other common side effects: headache, dry mouth, constipation, sweating, dizziness, sexual dysfunction.

Whom it may be suitable for: Depression sufferers with fatigue-like symptoms (norepinephrine works on the adrenal system); also a good option when SSRIs don’t work; not ideal for patients with hypertension.

Slower-onset, longer-acting benzodiazepines are preferred. All patients should be encouraged to try cognitive behavior therapy.

Augmentation therapy should be considered in patients who do not have a complete response.

Each type (class) of antidepressant affects these neurotransmitters in slightly different ways.

The goal in such development is to produce agents that are more efficacious, safer and better tolerated than older medications. Although all SSRI drugs have the same mechanism of action, each SSRI has slightly different pharmacological and pharmacokinetic characteristics.The degree of enzyme inhibition varies among SSRIs.Effects on blood levels and bioavailability of coadministered drugs, as well as pharmacodynamic interactions, account for most clinically significant SSRI-drug interactions.Drugs to consider for use in augmentation therapy include benzodiazepines, buspirone, beta blockers, tricyclic antidepressants, and valproate sodium.Effective management of panic disorder is a common challenge for family physicians.




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